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A novel classification method for aid decision of traditional Chinese patent medicines for stroke treatment

null

《医学前沿（英文）》 2017年第11卷第3期页码 432-439 doi: 10.1007/s11684-017-0511-1

摘要：

Traditional Chinese patent medicines are widely used to treat stroke because it has good efficacy in the clinical environment. However, because of the lack of knowledge on traditional Chinese patent medicines, many Western physicians, who are accountable for the majority of clinical prescriptions for such medicine, are confused with the use of traditional Chinese patent medicines. Therefore, the aid-decision method is critical and necessary to help Western physicians rationally use traditional Chinese patent medicines. In this paper, Manifold Ranking is employed to develop the aid-decision model of traditional Chinese patent medicines for stroke treatment. First, 115 stroke patients from three hospitals are recruited in the cross-sectional survey. Simultaneously, traditional Chinese physicians determine the traditional Chinese patent medicines appropriate for each patient. Second, particular indicators are explored to characterize the population feature of traditional Chinese patent medicines for stroke treatment. Moreover, these particular indicators can be easily obtained by Western physicians and are feasible for widespread clinical application in the future. Third, the aid-decision model of traditional Chinese patent medicines for stroke treatment is constructed based on Manifold Ranking. Experimental results reveal that traditional Chinese patent medicines can be differentiated. Moreover, the proposed model can obtain high accuracy of aid decision.

关键词： traditional Chinese patent medicines stroke aid decision data mining manifold ranking

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A PLATFORM TO AID SELECT THE OPTIMAL TOOL TO DESIGN GUIDE RNAS

《农业科学与工程前沿（英文）》页码 296-305 doi: 10.15302/J-FASE-2022479

摘要：

● Summaries on sgRNAs design.

关键词： CRISPR/Cas Aid-TG gene editing sgRNA design web server

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Generation and repair of AID-initiated DNA lesions in B lymphocytes

null

《医学前沿（英文）》 2014年第8卷第2期页码 201-216 doi: 10.1007/s11684-014-0324-4

摘要：

Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions.

关键词： class switch recombination somatic hypermutation activation-induced deaminase DNA repair genomic instability

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Estimation of photolysis half-lives of dyes in a continuous-flow system with the aid of quantitative

Davoud BEIKNEJAD,Mohammad Javad CHAICHI

《环境科学与工程前沿（英文）》 2014年第8卷第5期页码 683-692 doi: 10.1007/s11783-014-0680-y

摘要： In this paper the photolysis half-lives of the model dyes in water solutions and under ultraviolet (UV) radiation were determined by using a continuous-flow spectrophotometric method. A quantitative structure-property relationship (QSPR) study was carried out using 21 descriptors based on different chemometric tools including stepwise multiple linear regression (MLR) and partial least squares (PLS) for the prediction of the photolysis half-life ( ) of dyes. For the selection of test set compounds, a K-means clustering technique was used to classify the entire data set, so that all clusters were properly represented in both training and test sets. The QSPR results obtained with these models show that in MLR-derived model, photolysis half-lives of dyes depended strongly on energy of the highest occupied molecular orbital ( ), largest electron density of an atom in the molecule ( ) and lipophilicity (log ). While in the model derived from PLS, besides aforementioned and descriptors, the molecular surface area ( ), molecular weight ( ), electronegativity ( ), energy of the second highest occupied molecular orbital ( ) and dipole moment ( ) had dominant effects on logt values of dyes. These were applicable for all classes of studied dyes (including monoazo, disazo, oxazine, sulfonephthaleins and derivatives of fluorescein). The results were also assessed for their consistency with findings from other similar studies.

关键词： dye photolysis half-life quantitative structure-property relationship continuous-flow stepwise multiple linear regression partial least squares

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美国发布新规定以降低助听器购买门槛

Mitch Leslie

《工程（英文）》 2022年第14卷第7期页码 7-9 doi: 10.1016/j.eng.2022.05.008

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Convergence to real-time decision making

James M. TIEN

《工程管理前沿（英文）》 2020年第7卷第2期页码 204-222 doi: 10.1007/s42524-019-0040-5

摘要： Real-time decision making reflects the convergence of several digital technologies, including those concerned with the promulgation of artificial intelligence and other advanced technologies that underpin real-time actions. More specifically, real-time decision making can be depicted in terms of three converging dimensions: Internet of Things, decision making, and real-time. The Internet of Things include tangible goods, intangible services, ServGoods, and connected ServGoods. Decision making includes model-based analytics (since before 1990), information-based Big Data (since 1990), and training-based artificial intelligence (since 2000), and it is bolstered by the evolving real-time technologies of sensing (i.e., capturing streaming data), processing (i.e., applying real-time analytics), reacting (i.e., making decisions in real-time), and learning (i.e., employing deep neural networks). Real-time includes mobile networks, autonomous vehicles, and artificial general intelligence. Central to decision making, especially real-time decision making, is the ServGood concept, which the author introduced in an earlier paper (2012). It is a physical product or good encased by a services layer that renders the good more adaptable and smarter for a specific purpose or use. Addition of another communication sensors layer could further enhance its smartness and adaptiveness. Such connected ServGoods constitute a solid foundation for the advanced products of tomorrow which can further display their growing intelligence through real-time decisions.

关键词： real-time decision making services goods ServGoods Big Data Internet of Things artificial intelligence wireless communications

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Current applications of artificial intelligence for intraoperative decision support in surgery

Allison J. Navarrete-Welton, Daniel A. Hashimoto

《医学前沿（英文）》 2020年第14卷第4期页码 369-381 doi: 10.1007/s11684-020-0784-7

摘要： Research into medical artificial intelligence (AI) has made significant advances in recent years, including surgical applications. This scoping review investigated AI-based decision support systems targeted at the intraoperative phase of surgery and found a wide range of technological approaches applied across several surgical specialties. Within the twenty-one ( =21) included papers, three main categories of motivations were identified for developing such technologies: (1) augmenting the information available to surgeons, (2) accelerating intraoperative pathology, and (3) recommending surgical steps. While many of the proposals hold promise for improving patient outcomes, important methodological shortcomings were observed in most of the reviewed papers that made it difficult to assess the clinical significance of the reported performance statistics. Despite limitations, the current state of this field suggests that a number of opportunities exist for future researchers and clinicians to work on AI for surgical decision support with exciting implications for improving surgical care.

关键词： artificial intelligence decision support clinical decision support systems intraoperative deep learning computer vision machine learning surgery

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Challenges of human–machine collaboration in risky decision-making

《工程管理前沿（英文）》 2022年第9卷第1期页码 89-103 doi: 10.1007/s42524-021-0182-0

摘要： The purpose of this paper is to delineate the research challenges of human–machine collaboration in risky decision-making. Technological advances in machine intelligence have enabled a growing number of applications in human–machine collaborative decision-making. Therefore, it is desirable to achieve superior performance by fully leveraging human and machine capabilities. In risky decision-making, a human decision-maker is vulnerable to cognitive biases when judging the possible outcomes of a risky event, whereas a machine decision-maker cannot handle new and dynamic contexts with incomplete information well. We first summarize features of risky decision-making and possible biases of human decision-makers therein. Then, we argue the necessity and urgency of advancing human–machine collaboration in risky decision-making. Afterward, we review the literature on human–machine collaboration in a general decision context, from the perspectives of human–machine organization, relationship, and collaboration. Lastly, we propose challenges of enhancing human–machine communication and teamwork in risky decision-making, followed by future research avenues.

关键词： human–machine collaboration risky decision-making human–machine team and interaction task allocation human–machine relationship

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Erratum to: Theoretical foundation of a decision network for urban development

Shih-kung Lai, Jhong-you Huang,lai@tongji.edu.cn,jhongyouhuang@gmail.com

《信息与电子工程前沿（英文）》 2017年第18卷第10期页码 1677-1677 doi: 10.1631/FITEE.15e0000

摘要： Erratum to: , 2017 18(8):1033-1039. doi:

关键词： Decision making Linked decisions Decision network Planning

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CORRECTION to: Special issue: Decision, risk analytics and data intelligence

Xiaozhe ZHAO, Desheng Wu

《工程管理前沿（英文）》页码 697-697 doi: 10.1007/s42524-020-0139-8

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An overview on the applications of the hesitant fuzzy sets in group decision-making: Theory, support

Zeshui XU, Shen ZHANG

《工程管理前沿（英文）》 2019年第6卷第2期页码 163-182 doi: 10.1007/s42524-019-0017-4

摘要： Due to the characteristics of hesitant fuzzy sets (HFSs), one hesitant fuzzy element (HFE), which is the basic component of HFSs, can express the evaluation values of multiple decision makers (DMs) on the same alternative under a certain attribute. Thus, the HFS has its unique advantages in group decision making (GDM). Based on which, many scholars have conducted in-depth research on the applications of HFSs in GDM. We have viewed lots of relevant literature and divided the existing studies into three categories: theory, support and methods. In this paper, we elaborate on hesitant fuzzy GDM from these three aspects. The first aspect is mainly about the introduction of HFSs, HFPRs and some hesitant fuzzy aggregation operators. The second aspect describes the consensus process under hesitant fuzzy environment, which is an important support for a complete decision-making process. In the third aspect, we introduce seven hesitant fuzzy GDM approaches, which can be applied in GDM under different decision-making conditions. Finally, we summarize the research status of hesitant fuzzy GDM and put forward some directions of future research.

关键词： hesitant fuzzy set hesitant fuzzy preference relation group decision-making

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Clinical decision-making by the emergency department resident physicians for critically ill patients

null

《医学前沿（英文）》 2012年第6卷第1期页码 89-93 doi: 10.1007/s11684-012-0183-9

摘要：

The application of main methodologies for clinical decision-making by residents in emergency medical practice was assessed, and issues in this area were investigated. The treatments provided to 2 611 critical patients by the Peking Union Medical College Hospital of were analyzed by independent investigators who evaluated the main clinical decision-making processes applied by the hospital residents. The application of decision-making strategies by PG1 and PG3 groups, which means the residents in first year and the third year, were compared. The patients were treated according to pattern recognition (43.0%), hypothetico-deductive reasoning (23.4%), event-driven models (19.3%), and rule-using algorithms (5.9%). A significant difference was found between PG1 and PG3 groups (χ²=498.01, P<0.001). Pattern recognition and hypothetic-deductive methods were the most common techniques applied by emergency physicians in evaluating critically ill patients. The decision-making processes applied by junior and senior residents were significantly different, although neither group adequately applied rule-using algorithms. Inclusion of clinical decision-making in medical curricula is needed to improve decision-making in critical care.

关键词： clinical decision-making emergency medicine critically ill patient resident methodology

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双枝模糊决策与决策识别问题

史开泉,李歧强

《中国工程科学》 2001年第3卷第1期页码 71-77

摘要：

文章提出具有中性域X^*(X^*≠{x})X的上的双枝模糊决策的概念和决策优化分析模型、决策判定定理、决策识别定理、决策去余定理和决策因素域X上的挖洞原理。双枝模糊决策具有下列特征：决策结论的双向依赖特性，决策结论的叠加合成特性，决策结论的枝-分离特性，决策结论的枝-退化特性，决策结论的非失误特性。研究结果得到了应用。

关键词：双枝模糊决策决策模型决策判定定理决策识别定理决策去余定理挖洞原理

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BMP decision support system for evaluating stormwater management alternatives

Mow-Soung CHENG, Jenny X. ZHEN, Leslie SHOEMAKER,

《环境科学与工程前沿（英文）》 2009年第3卷第4期页码 453-463 doi: 10.1007/s11783-009-0153-x

摘要： Prince George’s County, Maryland, in the Washington D.C. metropolitan area has developed a best management practice decision support system (BMPDSS) to support analysis and decision making for stormwater management planning and design at both the site scale and the watershed levels. This paper presents a detailed description of the BMPDSS. A case study that demonstrates the application of the system is also included. The case study involves a Green Highway project located in a highly urbanized area within the Anacostia River watershed of the county. Several best management practices (BMP) such as bioretention, filter vegetative swale, porous paving, and landscape infiltration are proposed for reducing highway runoff and improving water quality. The BMPDSS is used to identify and evaluate various alternatives to determine the most cost-effective types and combinations of BMPs that minimize the highway runoff pollution.

关键词： best management practices decision support system low impact development geographic information system optimization